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24
th
ANNUAL SHORT COURSE ON EXPERIMENTAL MODELS OF HUMAN CANCER
August 15 - 22, 2015
Course Organizers:
Neal Copeland, Ph.D., The Houston Methodist Research Institute
Nancy Jenkins, Ph.D., The Houston Methodist Research Institute
Barbara Knowles, Ph.D.,The Jackson Laboratory
(adjunct)
Raju Kucherlapati, Ph.D., Harvard Medical School
Kevin Mills, Ph.D., The Jackson Laboratory
For more information please contact Laura Ingerson, laura.ingerson@jax.org
Draft Schedule -
subject to change
Saturday, August 15
2:00 PM
Arrival at Highseas anytime after 2:00 PM
Location – Highseas
4:30
Welcome and Course Introductions, students background with Barbara
Knowles and Students
5:30
Reception -
Highseas Lobby
6:00
Dinner – Highseas Dining Room
Sunday, August 16
6:30 – 7:30am
Breakfast – Highseas
7:30 - 8:15am
Van Transportation to GRB Training Lab & the LCC Auditorium
Location: The Jackson Laboratory LCC Auditorium
Background Sessions
8:00 – 9:00
Pathology and Histopathology of Normal and Neoplastic Tissue:
An Overview
Rosalinda Doty, DVM, The Jackson Laboratory
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Group A
Location: Main Lab - GRB Training Lab
9 – 12:00
Workshop: Pathology, Tissue Trimming,
and Necropsy
Jim Miller, The Jackson Laboratory
Group B
Location – Main Lab Auditorium
9 –9:45 Diversity Outbred Mice
Steve Munger, Ph.D. ,The Jackson Laboratory
9:45 – 10:30 ARTS and Managing Colonies from
the Freezer
Janice Pandola, Ph.D, The Jackson
Laboratory
10:30 – 11:15 KOMP
Steve Murray, Ph.D., The Jackson Laboratory
11:15 -12:00 The Jackson Laboratory facts and
tour
Barbara Knowles, Ph.D, and Kevin Mills, Ph.D
The Jackson Laboratory
12:00 - 1
Lunch- Roscoes
Group A
Location – Main Laboratory Auditorium
1:00-1:45 Diversity Outbred Mice
Steve Munger, Ph.D. ,The Jackson Laboratory
1:45 – 2:30 ARTS and Managing Colonies from
the Freezer
Janice Pandola,Ph.D., The Jackson
Laboratory
2:30 – 3:15 KOMP
Steve Murray, Ph.D., The Jackson Laboratory
3:15 – 4:00 Jackson Laboratory facts and tour
Barbara Knowles, Ph.D, Kevin Mills, Ph.D, , The
Jackson Laboratory
Group B
Location: Main Lab - GRB Training Lab
1:00 – 4:00
Workshop: Pathology, Tissue Trimming, and
Necropsy
Jim Miller, The Jackson Laboratory
Poster Session Reception - Roscoe’s and Lobby
4:00
Poster Session ( each students give a 2 minute presentation)
6:30
Dinner - Highseas Dining Room
7:30
Modeling Cancer in Mice Using Inducible shRNA and CRISPR/Cas9
Haoyi Wang, Ph.D., The Jackson Laboratory
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Monday, August 17
6:30 – 7:30am
Breakfast - Highseas
7:30 - 8:15am
Van Transportation to the LCC Auditorium
Location: The Jackson Laboratory LCC Auditorium
Fundamentals
8:20 AM
Review Course Evaluation Instructions
8:30
Mouse Genetics
Nancy Jenkins, Ph.D., The Methodist Hospital Research Institute
9:30
TBA
10:30
Break
11:00
Humanized Mouse Models for Cancer Research
Leonard D. Shultz, Ph.D, The Jackson Laboratory
12:00 PM Lunch – Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference Room
Stem Cells and Epigenetics
1:30
Cloning, imprinting and genomic reprogramming: the path to stem cells
Davor Solter, M.D., Ph.D., Max Planck Institute for Immunology and
Epigenetics
2:30
Pluripotency, stem cells and epigenetic reprogramming
Rudolf Jaenisch, M.D., Whitehead Institute
3:30
Break
4:00
Cancer Epigenetics
Peter Laird, Ph.D., Van Andel Research Institute
5:00
Van Transportation to Highseas
6:00
Dinner – Highseas Dining Room
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Tuesday, August 18
6:30 – 7:30am
Breakfast - Highseas
7:30 - 8:15am
Van Transportation to the LCC Auditorium
Location: The Jackson Laboratory LCC Auditorium
Stem Cells and Epigenetics – Modeling Cancer
8:30 AM Micro RNAs and Cancer
Carlo M. Croce, M.D., Ohio State University
9:30
Harnessing transposons for cancer gene discovery
Neal G. Copeland, Ph.D., The Houston Methodist Research Institute
10:30
Break
11:00
Viruses and Cancer
Peter Howley, M.D., Harvard Medical School
12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference
1:00
PDX & Bioinformatics
Carol Bult, Ph.D., The Jackson Laboratory
2:00
Break
Group A
Group B
2:30 – Bioinformatics and Data Bases
Steve Munger, Ph.D., and Guru Ananda,
Ph.D, The Jackson Laboratory
Location: GRB 3225
2:30 –
Xenografting
Bonnie Lyons, DVM,The Jackson Laboratory
Location: GRB training Lab
4:00 –
Xenografting
Bonnie Lyons, DVM,The Jackson Laboratory
Location: GRB training Lab
4:00 – Bioinformatics and Data Bases
Steve Munger, Ph.D., and Guru Ananda,
Ph.D, The Jackson Laboratory
Location: GRB 3225
5:30
Van Transportation to Highseas
6:00
Dinner – Highseas Dining Room
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Wednesday, August 19
6:30 – 7:30am
Breakfast - Highseas
7:30 - 8:15am
Van Transportation to the LCC Auditorium
Location: The Jackson Laboratory LCC Auditorium
Cancer Genomics
8:30
Modeling Human Cancers in the Mouse
Mario R. Capecchi, Ph.D., University of Utah School of Medicine
9:30
Break
10:00
4P Medicine - Glioblastoma
Lee Hood, Ph.D., Institute for Systems Biology
11:00
Stem Cells and Cancer
Irving L. Weissman, M.D., Stanford University School of Medicine
12:00 PM Lunch - Served in Roscoe’s
1:00
p53 and Cancer epilogue
Gigi Lozano, PhD., MD Anderson Cancer Center
2:00
Multiple Roles of P53
Arnold Levine, Ph.D., Rutgers Cancer Institute of New Jersey
3:00
Break
4:00
Biomedical Careers Discussion Panel with Faculty
Moderator: Raju Kucherlapati, Ph.D., Harvard Medical School
5:00
Reception for Short Course Faculty and Students
6:20
Van Transportation to Highseas
Dinner – On your own
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Thursday, August 20
6:30 – 7:30am
Breakfast Highseas
7:30 - 8:15am
Van Transportation to the LCC Auditorium
Location: The Jackson Laboratory LCC Auditorium
Discovery Approaches
8:30
Proteomic approaches to identifying new cancer markers
Sam Hanash, M.D., Ph.D., MD Anderson Cancer Center
9:30
TBA
10:30
Break
11:00
Sequencing the cancer genome
Elaine R. Mardis, Ph.D., The Genome Institute Washington University St. Louis
12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference Room
1:30
Single Cell Sequencing in Breast Cancer
Nick Navin, Ph.D., MD Anderson Cancer Center
Group A
Group B
2:30 – CRISPR / Cas
Michael Wiles, Ph.D., Wenning Qin, Ph.D,
and Ben Low, B.S, The Jackson Laboratory
Location: GRB Training Lab
2:30 –
Single Cell Sequencing
Paul Robson, Ph.D., The Jackson
Laboratory
Nick Navin, Ph.D., MD Anderson Cancer
Center
Location: GRB training Lab
4:00 –
Single Cell Sequencing
Paul Robson, Ph.D., The Jackson
Laboratory
Nick Navin, Ph.D., MD Anderson Cancer
Center
Location: GRB 3225
4:00 – CRISPR / Cas
Michael Wiles, Ph.D., Wenning Qin, Ph.D,
and Ben Low, B.S, The Jackson Laboratory
Location: Training Lab
5:30
Van Transportation to Highseas
6:00
Lobster Dinner – Highseas Dining Room
7:30pm
Animal Ethics workshop
Peggy Danneman, V.M.D., M.S., ACLAM., The Jackson Laboratory
Friday, August 21
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6:30 – 7:30am
Breakfast - Highseas
7:30 - 8:15am
Van Transportation to the LCC Auditorium
Location: The Jackson Laboratory LCC Auditorium
Therapeutic Intervention
8:30
Targeting the Hedgehog pathway in cancer: From Bench to Clinic
Frederic de Sauvage, Ph.D., Genentech
9:30
Pancreatic cancer treatment strategies
David Tuveson, M.D. Ph.D., Cold Spring Harbor Laboratory
10:30
Break
11:00
Mouse Hospital
Pier Paolo Pandolfi, M.D., Ph.D., Beth Israel Deaconess Cancer Center/ Harvard
Medical School
12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference Room
1:30
Targeted therapies in Lung Cancer
Bruce Evans Johnson, M.D., Dana-Farber / Harvard Cancer Center
2:30
Genomics and Cancer
Edison Liu , M.D., The Jackson Laboratory
3:30
Break
4:00
Zebrafish Models to Dissect Human Cancer Pathways
A. Thomas Look, M.D., Dana Farber Cancer Institute
5:00pm
Van Transportation to Highseas
6:00
Dinner – Highseas Dining Room
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Saturday, August 22
7:00 – 8:00am
Breakfast
– Highseas
Cancer Therapeutics
Lecture Location: HighSeas 3
rd
Floor Lecture Room
8:30
Mechanisms of Malignant Progression
Robert Weinberg, Ph.D., Whitehead
10:30
Break
11:00
Tumor Angiogenesis and Microenvironment
Rakesh Jain, Ph.D., Massachusetts General Hospital
12:00PM Lunch with faculty at HighSeas
Lecture Location: HighSeas 3
rd
Floor Lecture Room
1:00
Cancer Immunotherapies
Karolina Polucka, Ph.D., The Jackson Laboratory
2:00
Break
2:30
Synthetic Lethal Therapy
Kevin Mills, Ph.D., The Jackson Laboratory
3:30
Strategy for Future Anti-cancer Therapeutics: Put the Cart Before the
Horses”
Tak Mak, Ph.D., The Campbell Family Institute for Breast Cancer Research at
5:00
End of the course
6:00
Dinner - Highseas Dining Room
